Similarly, in their existential confusion, Vladimir and Estragon struggle to grasp their existence's significance or purpose. They are "blind" to the larger meaning of their lives and the passage of time. Moreover, Beckett's statement hints at the theme of isolation and alienation. The characters in the play are isolated from the world and each other. Their inability to understand time deepens this isolation, as it emphasizes their disconnection from life's everyday rhythms and routines.

This line highlights the absurdity of human existence and the search for meaning. In the context of the play, it suggests that pursuing purpose or understanding may be futile and that individuals like Vladimir and Estragon may find themselves in an endless state of waiting, unable to learn the inaccessible concept of time or the meaning of their existence. Beckett's work challenges the audience to experience the inherent absurdity of the human condition and to reflect on how we wrestle with the passage of time and the search for meaning in a seemingly indifferent world.